FAS and FAS-Ligand Promoter Polymorphisms in Hepatitis B Virus Infection
نویسندگان
چکیده
منابع مشابه
fas and fas-ligand promoter polymorphisms in hepatitis b virus infection
objectives thus, the present study aimed to determine if fas and fasl promoter polymorphisms are associated with the clinical outcome of hbv infection. patients and methods dna samples were obtained from the infected individuals including chronic carrier (n = 50), chronic hepatitis (n = 50), cirrhosis (n = 25), naturally recovered (n = 26) and compared with those of their matched healthy contro...
متن کاملFAS and FAS-Ligand Promoter Polymorphisms in Hepatitis B Virus Infection
BACKGROUND The FAS and FAS-Ligand (FASL) system is an important apoptosis pathway in the liver. The FAS-mediated pathway functions by binding the FASL on the activated cytotoxic T lymphocytes and Natural Killer (NK) cells to the FAS receptor on infected hepatocytes. FAS and FASL polymorphisms, which are related to apoptosis, might influence the outcome of Hepatitis B Virus (HBV) infection. OB...
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Background: The First apoptosis signal (FAS) and First apoptosis signal ligand (FASL) genes initiate the apoptosis pathway, playing a central role in the tumor growth and metastasis. Gene polymorphisms including -1377 G/A in the promoter region of FAS and -844 C/T in the promoter region of FASL have shown to change the transcription activities of these genes. Methods: In this study we evalua...
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The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas. We report here that chronic expression of Nur77/N10 in thymocytes of transgenic mice results in a dramatic reduction of CD4+CD8+ double-positive as well as CD4+CD8and CD4-CD8+ single-positive cell populations due to an early onset ofapoptosis. CD4-CD8double-negative and CD25+ p...
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ژورنال
عنوان ژورنال: Hepatitis Monthly
سال: 2015
ISSN: 1735-143X,1735-3408
DOI: 10.5812/hepatmon.26490